Definition

Zoledronate is also known as Zometa. It is a treatment for hypercalcemia (high levels of calcium in the blood) caused by tumors. New laboratory evidence suggests that, in addition, zoledronate may have direct anticancer effects.

Purpose

Tumor-induced hypercalcemia is also known as hyper-calcemia of malignancy. Tumor-induced hypercalcemia may be caused by a tumor spreading to and causing breakdown of bone, or by chemicals released from some tumors. The result is high levels of calcium in the blood. High levels of calcium may cause changes in mental status, constipation, and kidney damage.

Zoledronate is being investigated as a treatment for bone metastases. Bone metastases may develop if...